Shared genetic architecture between anxiety, depression and erectile dysfunction: a genome-wide cross-trait analysis.

ABSTRACT:

Background

The epidemiological association between erectile dysfunction (ED) and anxiety/depression has been extensively studied; however, the underlying genetic mechanisms remain elusive. This study aimed to investigate the shared genetic architecture linking ED with depression and anxiety disorders, and to identify common risk loci, associated genes, and underlying genetic mechanisms.

Methods

Based on a large-scale genome-wide association study (GWAS) summary-level, genetic overlaps were identified between two common mental health problems (anxiety and depression) and ED (223,805 participants). Depression-related phenotypes: depression (finngen_R12_F5_DEPRESSIO, 494,164 participants), major depression (ieu-b-102, 500,199 participants), mental health problemsever diagnosed

SUBMITTER: Xie L 

PROVIDER: S-EPMC12541498 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature