Nomogram for predicting acute kidney disease in patients with upper tract urothelial carcinoma undergoing adjuvant chemotherapy following radical nephroureterectomy.

ABSTRACT:

Background

Radical nephroureterectomy (RNU) with complete bladder cuff excision is the primary treatment for high-risk non-metastatic upper urinary tract urothelial carcinoma (UTUC). Gemcitabine-platinum combination chemotherapy is established as the preferred adjuvant therapy post-RNU; however, both RNU and platinum-based therapies can significantly impair renal function. This study aimed to construct a nomogram to predict acute kidney disease (AKD) occurrence in UTUC patients undergoing gemcitabine-platinum chemotherapy after RNU.

Methods

We collected data from patients who underwent RNU followed by adjuvant gemcitabine-platinum chemotherapy at Beijing Friendship Hospital, Capital Medical University, between September 2015 and September 2024. Demographic, perioperative, an

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12541500 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature