A narrative review of the distribution and role of multipotent fibroblasts in penile tissue: implications for regenerative medicine and erectile dysfunction.

ABSTRACT:

Background and objective

Erectile dysfunction (ED) is a common male sexual disorder with multifactorial etiologies, including diabetes mellitus and cavernous nerve injury. Recent developments in single-cell RNA sequencing (scRNA-seq) have revealed substantial cellular heterogeneity within the corpus cavernosum, especially among fibroblast (FB) subclusters. This review aims to delineate the roles of these FB subclusters and their extracellular vesicles (EVs) in the pathogenesis and potential treatment of ED.

Methods

A comprehensive literature review was conducted focusing on studies utilizing scRNA-seq to analyze human and murine corpus cavernosum tissues under physiological and ED-associated conditions. Key findings regarding FB subcluster classification, transcriptomic land

SUBMITTER: Fridayana FR 

PROVIDER: S-EPMC12541504 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature