Decellularized rat tubules for tissue engineering.

ABSTRACT:

Background

Chronic kidney disease (CKD) remains a global health challenge, with tissue engineering strategies like decellularized scaffolds offering potential solutions for functional renal regeneration, yet hindered by the complexity of whole-organ recellularization. Since the recellularization process is limited in whole organs, we propose to decellularize renal tubules and assess whether they exhibit enhanced recellularization potential, thereby offering a novel strategy for kidney regeneration.

Methods

This study presents a microscale approach utilizing decellularized rat renal tubules to address these limitations. Renal tubules were microdissected from rat kidneys and then subjected to decellularization treatment with 0.5% sodium dodecyl sulfate (SDS) for 2 minutes. The

SUBMITTER: Jia Q 

PROVIDER: S-EPMC12541505 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature