Zhenyuan, a kidney- and spleen-tonifying Chinese medicine compound granule, improves erectile dysfunction and fatigue in orchiectomized rats.

ABSTRACT:

Background

The kidney and spleen are associated with erectile dysfunction (ED) in traditional Chinese medicine (TCM) understanding. Zhenyuan granule (ZYKL) is a Chinese herbal formula with the function of tonifying kidney and spleen and promoting blood circulation. This study aims to evaluate the effects of ZYKL on improving ED and fatigue.

Methods

A rat model of orchiectomy (ORX) was developed by removing bilateral testicles. Male Sprague-Dawley rats were divided into Sham, ORX, testosterone (T) propionate (2 mg/kg), ZYKL low-dose (0.94 g/kg), ZYKL middle-dose (3.76 g/kg), and ZYKL high-dose (7.52 g/kg) group. Rats in ZYKL groups were given ZYKL by gavage for 21 days. Sexual behavior parameters, including erection latency (EL), mount latency (ML), and mount frequency (MF),

SUBMITTER: Yang RY 

PROVIDER: S-EPMC12541520 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature