Heart Rate Variability Biofeedback and Mental Stress Myocardial Flow Reserve: A Randomized Clinical Trial.

ABSTRACT:

Importance

Heart rate variability biofeedback (HRVB) is a self-regulation intervention that targets autonomic nervous system activity through guided breathing and visualization. Investigating its effects on cardiovascular responses to psychological stress may clarify its therapeutic potential for patients with coronary artery disease (CAD).

Objective

To examine the effects of HRVB on myocardial blood flow (MBF) changes during a mental stress challenge in individuals with CAD.

Design, setting, and participants

This single-center pilot randomized clinical trial included participants aged 30 to 79 years with CAD recruited in a university hospital setting and enrolled from March 30 to November 9, 2016 (data were analyzed from January to August 2025 for final reporting). P

SUBMITTER: Shah AJ 

PROVIDER: S-EPMC12541537 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature