Low Body Mass Index as a Predictor of Amiodarone-Induced Pulmonary Toxicity.

ABSTRACT:

Background

Amiodarone-induced pulmonary toxicity (APT) is one of the major side effects of the medication when used in the treatment of arrhythmia. However, the risk factors for developing APT have yet to be fully understood.

Methods and results

We retrospectively analyzed 454 patients who were treated with amiodarone for arrhythmia between 2016 and 2020 at the National Cerebral and Cardiovascular Center, Osaka, Japan. During the median follow-up period of 207 days, 24 patients (5.4%) had APT. Using a multivariate analysis of the Cox proportional hazards model, lower body mass index (BMI) (hazard ratio [HR]: 0.81, 95% confidence interval [CI]: 0.71-0.95), higher age (HR: 1.06, 95% CI: 1.02-1.10), and higher amiodarone maintenance dose (HR: 1.01, 95% CI: 1.003-1.02) were risk

SUBMITTER: Zaizen T 

PROVIDER: S-EPMC12541544 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature