Outcomes With Pulsed Field Ablation Versus Conventional Thermal Ablation for Paroxysmal Atrial Fibrillation: A Meta-Analysis.

ABSTRACT:

Background

Pulmonary vein isolation is a standard therapy for paroxysmal atrial fibrillation (AF). Pulsed field ablation (PFA) has emerged as a novel approach aiming to improve efficacy and safety over conventional thermal ablation (CTA) (radiofrequency and cryoballoon). This meta-analysis evaluated outcomes of PFA versus thermal ablation in paroxysmal AF.

Methods

Electronic databases were searched through May 2025 for randomized controlled trials (RCTs) and observational studies that compared the efficacy and safety of PFA versus CTA. The primary outcome was AF recurrence. Summary estimates were conducted using random effects.

Results

A total of six studies, involving 1928 patients, were included. The incidence of AF recurrence was significantly lower among patients

SUBMITTER: Mohamed AE 

PROVIDER: S-EPMC12541548 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature