Early pembrolizumab clearance as prognostic biomarker for non-response in patients with advanced non-small cell lung cancer.

ABSTRACT: Immune checkpoint inhibitors have improved survival rates in patients with advanced-stage non-small cell lung cancer; however, the majority obtain no long-term benefits. We investigated pembrolizumab clearance as an early prognostic biomarker and evaluated its accuracy using a limited sampling strategy. Pembrolizumab clearance was calculated using non-linear mixed effects modeling, and cut points were determined using maximally selected rank statistics. The prognostic value for survival was estimated using univariate Cox regression analysis. Sensitivity, specificity, and positive and negative predictive values were calculated to evaluate the performance in identifying response (defined as disease control at 6 months). The accuracy of a limited sampling strategy was evaluated using MPE and

SUBMITTER: de Vries F 

PROVIDER: S-EPMC12541564 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature