Design and initial findings of a natural history study of anal HPV and associated lesions among young adult women in Costa Rica.

ABSTRACT: Anal cancer is caused by HPV, and its incidence has increased globally over the last five decades. We conducted an anal HPV natural history study nested in the Costa Rica HPV Vaccine Trial (CVT) to quantitatively describe the natural history and clinical outcomes of anal HPV in HIV-negative women. CVT was a randomized clinical trial of the bivalent HPV vaccine, and an anal substudy included women selected based on a priori criteria to enrich for anal disease. For women in the anal substudy, anal samples were collected for cytology and determination of HPV16/18/45 for up to four annual visits. Women were referred for high-resolution anoscopy (HRA) based on abnormal anal cytology or anal HPV16/18/45 positivity. We describe the analytic cohort for this study according to inclusion criteria an

SUBMITTER: Haas CB 

PROVIDER: S-EPMC12541566 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature