Cerium single-atom catalysts-armed <i>Lactobacillus reuteri</i> for multipronged anti-inflammatory/anti-fibrotic therapy of inflammatory bowel disease.

ABSTRACT: Simultaneous management of intestinal mucosal barrier dysfunction and gut microbiota dysregulation represents a significant challenge in the treatment of inflammatory bowel disease (IBD). Herein, we report a novel system that integrates multi-enzyme mimicking cerium single-atom nanocatalysts (CeSACs) with Lactobacillus reuteri probiotics (LR@CeSACs) for multipronged management of IBD. In this system, CeSACs demonstrate robust multi-enzyme activities across a broad pH range, effectively scavenging elevated reactive oxygen species, downregulating pro-inflammatory cytokines, and suppressing the expression of fibrosis-related genes. Moreover, probiotics promote the targeting and retention of the CeSACs for sustained catalytic antioxidant therapy. In turn, the inflammation relief enabled

SUBMITTER: Pu Y 

PROVIDER: S-EPMC12541580 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature