Interactions between lorcaserin and opioids: Ventilation and food-versus-drug choice.

ABSTRACT: Lorcaserin, a selective serotonin 2C (5-HT_2C) receptor agonist, was approved for treating obesity and has been investigated for treating substance use disorders including those involving opioids. Although lorcaserin was withdrawn from the market, interest in the therapeutic potential of drugs acting at 5-HT_2C receptors continues, supporting the need to further characterize potential adverse effects especially when combined with drugs of abuse. This study examined acute effects of lorcaserin on opioid-induced ventilatory depression, which is the primary cause of overdose, and opioid self-administration, which models factors contributing to opioid abuse, in male and female rhesus monkeys. In one group (n = 4), effects of morphine (0.178 to 5.6 mg/kg, s.c.), fentanyl (0.

SUBMITTER: Maguire DR 

PROVIDER: S-EPMC12541597 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature