Pentavalent rotavirus vaccine effectiveness among children in Shenzhen, China: A population-based test-negative design with directed acyclic graphs bias adjustment.

ABSTRACT:

Background

China's Notifiable Disease Reporting System comprehensively collects data on pediatric acute gastroenteritis cases from all levels of healthcare. This study evaluated the effectiveness of the pentavalent rotavirus vaccine against rotavirus gastroenteritis in children under five years of age during seasonal epidemic periods.

Methods

Using a test-negative design, we analyzed laboratory data from diarrhea patients aged 2-59 months who sought medical care in Longhua District, Shenzhen, Guangdong Province, China between January 2020 and March 2024. Vaccination history and potential confounders, including sex, household registration status, prematurity, and birth weight, were collected retrospectively. Directed acyclic graphs were used to identify adjustment variables.

SUBMITTER: Lin Z 

PROVIDER: S-EPMC12541608 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature