Post-Thyroidectomy Opioid Prescription and Risk of Persistent Opioid Use: A Propensity Matched Cohort Study.

ABSTRACT:

Background

This study evaluates the risk of persistent opioid use (POU) among thyroidectomy patients given postoperative opioids.

Methods

Patients undergoing thyroidectomy were identified using the TriNetX Research Platform (2010-2024). Cohorts were divided based on opioid prescriptions on the day of surgery. With propensity score matching to prevent confounding bias, risk ratios were calculated for opioid prescriptions 3-9 months post-surgery. Secondary outcomes included ED presentation, pain diagnosis, and lifetime risk of opioid use disorder, defined as significant social dysfunction due to uncontrolled use.

Results

The post-match opioid group (n = 19,727) experienced a 4.61% risk of POU (control: 4.07%), representing a 14% higher risk of POU compared to the non-op

SUBMITTER: Ayo-Ajibola O 

PROVIDER: S-EPMC12541683 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature