Soy Isoflavones Prevent Bone Quality Loss Induced by High-Fat Diet in Rats Through Epigenetic Modifications.

ABSTRACT: Chronic consumption of a Western-style diet, high in saturated fats and cholesterol, disrupts energy metabolism, leading to obesity and insulin resistance. In contrast, isoflavone (Isof)-rich soy has been shown to benefit connective tissue metabolism. However, the potential of soy Isof dietary supplementation to counteract the effects of a high-fat diet (HFD) on bone development, morphology, and remodeling remains poorly understood. In this study, 24-day-old male Sprague-Dawley rats were fed a HFD containing 45% fat and 0.25% cholesterol for 8 weeks, leading to significant increases in body weight, long bone length, bone marrow adiposity, and insulin resistance when compared to control diet (AIN-93G) rats. Using micro-CT and three-point bending tests, we found that supplementation of HFD w

SUBMITTER: Caviness PC 

PROVIDER: S-EPMC12541691 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature