Dual Action Nitric Oxide-Releasing Polydimethylsiloxane Sponge: Preventing Infection in Needleless Connectors.

ABSTRACT: Catheter-related bloodstream infections (CRBSIs) are a prevalent concern, often resulting from suboptimal disinfection practices of needleless connectors. Although alcohol-based disinfectants have demonstrated efficacy, there is growing concern about developing microbial resistance. Similar to antibiotics in recent decades, microbes have the potential to develop resistance to these alcohol-based therapies. Therefore, this study delves into the antimicrobial potential of nitric oxide (NO), an endogenous gas molecule with broad-spectrum antimicrobial properties, in combination with the widely used disinfectant 70% isopropanol (IPA). Due to its short half-life, NO presents minimal risk of microbial resistance development. By incorporating S-nitroso-N-acetylpenicillamine (SNAP),

SUBMITTER: Goodman AB 

PROVIDER: S-EPMC12541702 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature