Ultrasensitive Direct Chemical Analysis of Human Hair Using Proton Transfer Reaction Time-of-Flight Mass Spectrometry (PTR-TOF-MS) for Nontargeted Exposure Profiling.

ABSTRACT: Exposure to air pollution plays a significant role in human health. Current methods of measuring human exposure are often limited to outdoor measurements, are time intensive, or are unable to accurately measure certain classes of compounds. This study proposes human hair as a promising indicator of pollution exposure. We present a novel method of hair analysis involving thermal extraction and detection of semivolatile organic compounds using a Vocus 2R proton transfer reaction time-of-flight mass spectrometer (Vocus PTR-TOF-MS). The hair samples were subjected to a temperature ramp spanning three different temperatures: 60 °C, 90 °C, and 120 °C. A hierarchical clustering approach was used to create "clustergrams", dendrograms comprising chemical fingerprints of the hair samples at each dif

SUBMITTER: Neville AC 

PROVIDER: S-EPMC12541802 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature