Mechanochemical Extrusion for Sustainable Synthesis of Amides and Amines via the Leuckart Reaction.

ABSTRACT: An extrusion-based, solvent-free method was developed for the synthesis of amides and amines via the Leuckart reaction, representing the first adaptation of this classical transformation into a continuous mechanochemical platform. The production of amides was demonstrated through the model reaction between ammonium formate and vanillin, leading to vanillyl formamide, while the synthesis of tertiary amines was investigated using ammonium formate, vanillin, and morpholine as reactants. A thorough parametric analysis revealed that the mechanochemical-based strategy allowed extremely fast processes: at 100-150 °C, reactions were quantitative in 5-15 min with product selectivity >99% for vanillin formamide and up to 83% for the corresponding tertiary amine. An investigation of the substrate sco

SUBMITTER: Zorzetto F 

PROVIDER: S-EPMC12541804 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature