Density and maturity ratio of tertiary lymphoid structures in stage II-III non-small cell lung cancer predict postoperative recurrence risk.

ABSTRACT:

Background

Tertiary lymphoid structure (TLS) has been proposed to assess the prognosis of patients with cancer. Due to the heterogeneity of the tumor microenvironment, TLS varies significantly in tumor tissues of different patients. This study aims to explore TLS in tumor tissues from patients with stage II-III non-small cell lung cancer (NSCLC) and their impact on postoperative recurrence risk.

Methods

A total of 118 patients who underwent curative surgery for pathologically confirmed primary stage II-III NSCLC were included in this study. The density of TLS in tumor tissue was assessed using hematoxylin and eosin (HE) stained sections. Multiplex immunofluorescence was employed to evaluate the maturity of TLS by labeling follicular dendritic cells (FDC) and germinal centers

SUBMITTER: Liu YM 

PROVIDER: S-EPMC12541829 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature