Multimodal prehabilitation to prevent loss of cardiorespiratory fitness in patients with locally advanced lung cancer undergoing chemoimmunotherapy: protocol for a non-randomized multicentre study.

ABSTRACT:

Background

Non-small cell lung cancer (NSCLC) is the second most common cancer globally and a leading cause of cancer-related mortality. Although 5-year survival rates remain lower than those of other cancer types, significant improvements have been observed in recent years, largely due to the introduction of immunotherapy and targeted therapies. Recently, immune checkpoint inhibitors (ICIs) have been approved for use in combination with standard double-platinum chemotherapy in the neoadjuvant setting for resectable NSCLC, improving outcomes and extending time to recurrence. However, neoadjuvant therapy (NAT) can lead to declines in pulmonary function and cardiorespiratory fitness (CRF), thereby increasing the risk of postoperative complications. This study aims to evaluate the eff

SUBMITTER: Chen YX 

PROVIDER: S-EPMC12541833 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature