The difference in tumor immune microenvironment and IFN-γ response between solid and non-solid adenocarcinoma.

ABSTRACT:

Background

Solid subtype adenocarcinomas have poor prognosis. Interferon-γ (IFN-γ) is a critical cytokine related to anti-tumor response in the tumor immune microenvironment. We aimed to identify the prognostic factors related to IFN-γ responsiveness.

Methods

A total of 112 lung adenocarcinoma samples were obtained from patients who underwent surgery between 2014 and 2020. DNA and RNA were extracted and analyzed. Additionally, the Cancer Genome Atlas dataset of patients with lung cancer was accessed. We classified adenocarcinomas using single-sample gene set enrichment analysis based on IFN-γ response pathway expression to elucidate the genomic profile and prognosis.

Results

The tumor immune microenvironment is immunologically hot, with higher immune cell infiltration

SUBMITTER: Shinohara S 

PROVIDER: S-EPMC12541845 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature