An effective and affordable blood test for lung cancer early detection using four protein markers and artificial intelligence.

ABSTRACT:

Background

Lung cancer constitutes the leading cause of cancer mortality globally. This study assessed LungCanSeek, a novel blood-based protein test for lung cancer early detection.

Methods

This retrospective study enrolled 1,814 participants (1,095 lung cancer, 719 non-cancer) from three different cohorts. Blood samples were analyzed for four protein tumor markers (PTMs) using Roche cobas. Artificial intelligence (AI) algorithms were developed for lung cancer detection and subtype classification: lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), and small cell lung cancer (SCLC). A two-step approach was modeled, using LungCanSeek for initial screening, followed by low-dose computed tomography (LDCT) for LungCanSeek's positive cases.

Results

LungCanSeek

SUBMITTER: Wei B 

PROVIDER: S-EPMC12541848 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature