Biomarkers for non-small cell lung cancer risk using multi-omics approaches: a nested case-control study.

ABSTRACT:

Background

Lung cancer poses a major public health challenge, accounting for the highest cancer-related mortality worldwide. This study aimed to identify non-invasive biomarkers for the early detection of non-small cell lung cancer (NSCLC) risk.

Methods

We randomly selected 150 incident NSCLC cases during follow-up from the Korean Cancer Prevention Study-II. Controls (n=150) were matched to cases by age, gender, and the time of blood collection. Non-targeted metabolite screening by ultra-high-performance liquid chromatography (UHPLC)/mass spectrometry (MS) was conducted on the pre-diagnostic biological samples. The 11 reported lung cancer-associated single-nucleotide polymorphisms (SNPs) in Koreans were extracted from DNA genotyping data of the study population. Metabolite m

SUBMITTER: Han Y 

PROVIDER: S-EPMC12541849 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature