Molecular and clonal evolution of primary lesions <i>vs.</i> brain metastasis in <i>EGFR</i>-mutated NSCLC: a retrospective cohort study.

ABSTRACT:

Background

Clonality is an intrinsic phenomenon of disease evolution, with specific clones conferring increased aggressiveness. We aimed to evaluated the different divergent and unique mutational patterns in brain metastases (BM).

Methods

This retrospective cohort study included patients with epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma and BM. All the patients underwent three next-generation sequencing (NGS)-based genomic profiling assessments. Two analyses involved tissue samples from the lung and brain lesions, whereas the third utilized either liquid or tissue biopsy. Treatment consisted of Osimertinib and Stereotactic radiosurgery.

Results

Thirty patients were included (73% female). Central nervous system (CNS) involvement was noted

SUBMITTER: Ruiz-Patino A 

PROVIDER: S-EPMC12541880 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature