Association Between Serum Micronutrients and Advanced CKM Syndrome: An Interpretable Machine Learning-Based Study.

ABSTRACT: CKM is a common systemic disorder characterized by pathological and physiological interactions between the cardiovascular system. In recent years, the intake of micronutrients has been considered to be associated with CVD, CKD, and other conditions. However, the association between serum micronutrients and advanced CKM syndrome is still unclear. This study utilized data from the NHANES to analyze 6 serum micronutrients and employed the Boruta algorithm for feature selection. Subsequently, the risk of advanced CKM syndrome was predicted using 7 ML models. Additionally, SHAP and PDPs were employed to analyze the effects of serum micronutrients on advanced CKM syndrome. Results indicate that lower levels of β-carotene, α-tocopherol, lycopene, vitamin C, and 25(OH)D are associated with an incr

SUBMITTER: Ou Y 

PROVIDER: S-EPMC12541883 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature