Glia Preserve Their Own Functions While Compensating for Neighboring Glial Cell Dysfunction.

ABSTRACT: Glial cells are essential for nervous system development, homeostasis, and disease response, engaging in close interactions with neurons and other glial cells to carry out their functions. A large focus of glial studies has been on investigating how these cells work with neurons to execute their supportive roles, yet glial-glial interactions are even less well understood. Our previous work established that the loss of the secreted neurotrophin, Spätzle 3 (Spz3), from Drosophila cortex glia (CG) results in the morphological degradation of CG during mid to late larval development, where they lose their intricate interactions with neurons and other glial subtypes. Building on this work, we found that the loss of CG-neuron interactions triggers aberrant infiltration and functional compensation

SUBMITTER: Beachum AN 

PROVIDER: S-EPMC12541895 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature