Unraveling the Role of Ensheathing Cells and Perineural Fibroblasts in Olfactory Neurogenesis.

ABSTRACT: During development and following injury-induced neurogenesis, olfactory ensheathing cells (OECs) envelope the axon bundles of sensory neurons and support their growth to the glomerular destinations in the olfactory bulb. Transplantation of OECs to various neuronal injury locations showed a reparative impact; however, there was huge variability. By combining mRNA sequencing with bioinformatics analysis and immunohistochemistry, we characterized the cellular and molecular biological properties of OECs of the lamina propria and their response to neuronal injury. We found that OECs do not express NGFR (p75) under steady state conditions, questioning the common approach of isolating OECs with NGFR antibodies. While OECs express a peculiar combination of markers of different types of glial cells

SUBMITTER: Senf K 

PROVIDER: S-EPMC12541900 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature