Investigating the effects of circadian rhythm on the human skin lipidome.

ABSTRACT: The circadian rhythm is a 24 h cycle that harmonises the activity of organs - including the skin - to a daily routine using neurological and hormonal signals. Limited research has been done to understand the effects of the circadian rhythm on the skin lipidome. We used reversed-phase liquid chromatography-mass spectrometry (RPLC-MS) in a longitudinal study to investigate temporal changes to the skin lipidome over a 24 h cycle for eight healthy participants. All statistical analyses were performed with a group-mean and individual-mean data approach. Using cosinor analysis p-values, a total of 29 metabolites (0.67% of all detected metabolites) exhibited a statistically significant circadian rhythmicity across participants; however, individually, a range of 3.51-18.53% of metabolites w

SUBMITTER: Gehin C 

PROVIDER: S-EPMC12541903 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature