Global burden of liver cirrhosis: trends from 1990-2021 and projections to 2060.

ABSTRACT:

Background

Liver cirrhosis, a progressive and debilitating condition characterized by extensive fibrosis and disruption of hepatic architecture, remains a significant global health challenge, primarily arising from chronic hepatitis and other liver diseases.

Methods

Data from the 2021 Global Burden of Disease (GBD) database were utilized to analyze trends in the incidence, deaths, disability-adjusted life years (DALYs), and prevalence of liver cirrhosis from 1990 to 2021 across various geographic regions, aiming to provide guidance for future disease burden interventions. The Bayesian age-period-cohort (BAPC) model was utilized for predicting trends up to 2060.

Results

In 2021, the global incidence of liver cirrhosis was recorded at 58,417,006 cases. Total death cases

SUBMITTER: Luo X 

PROVIDER: S-EPMC12541949 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature