Neurobiological correlates of Mild Behavioral Impairment: a systematic review and meta-analysis.

ABSTRACT:

Background

Although individuals with Mild Behavioral Impairment (MBI) show an increased rate of developing dementia, it remains uncertain whether MBI should be considered a risk factor or an actual early sign of neurocognitive disease.

Objectives

This systematic review and meta-analysis aimed to explore the association between MBI and neurobiological correlates of dementia.

Methods

The study protocol followed PRISMA guidelines and was registered in PROSPERO (CRD42024589059). Five databases and gray literature were systematically searched from inception to January 31, 2025 to identify studies that explored the relationship between MBI and brain imaging findings or neurodegenerative and neuroinflammatory fluid biomarker levels. When studies employed comparable methodolo

SUBMITTER: Remelli F 

PROVIDER: S-EPMC12541964 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature