Diagnostic performance of a 250-ml net ultrafiltration challenge to identify risk of preload-dependence in critically ill patients undergoing continuous renal replacement therapy: a randomized, cross-over trial.

ABSTRACT:

Introduction

During continuous renal replacement therapy (CRRT), preload-independent patients risk of becoming preload-dependent in case of excessive net ultrafiltration (UF_NET). We aimed to evaluate the ability of a UF_NET challenge to identify de novo preload-dependence in preload-independent patients undergoing CRRT.

Materials and methods

We conducted a single-center, randomized, cross-over trial, enrolling adult patients with CRRT, calibrated continuous cardiac index (CCI) monitoring, and preload-independent at time of enrolment. The diagnostic test consisted of 250-ml UF_NET removal over 15 (fast challenge) or 30 min (slow challenge), preceded and followed by a postural maneuver (PM) evaluating preload-dependence using CCI relative variati

SUBMITTER: Biscarrat C 

PROVIDER: S-EPMC12541968 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature