Clinical pathological significance and biological functions of APIP in hepatocellular carcinoma.

ABSTRACT:

Background & aims

Hepatocellular carcinoma (HCC) is among the most common malignant tumors globally, characterized by high morbidity and mortality. This study aims to investigate the clinical and pathological significance of Apaf-1-interacting protein (APIP) expression in HCC, assess its biological effects on HCC cells, and explore the underlying mechanisms.

Methods

Internal tissue samples were analyzed to determine APIP expression and its clinical relevance in HCC using real-time quantitative polymerase chain reaction (RT-qPCR) and immunohistochemistry (IHC). External datasets were employed for verification. Experiments investigating cell proliferation, cell cycle progression, apoptosis, migration, and invasion were performed to understand the biological role and molecular

SUBMITTER: Yu C 

PROVIDER: S-EPMC12541992 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature