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Immunomodulation and iron dysregulation: exploring their roles in the pathogenesis of osteoarthritis.

ABSTRACT:

SUBMITTER: Yang D

PROVIDER: S-EPMC12542007 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature

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Immunomodulation and iron dysregulation: exploring their roles in the pathogenesis of osteoarthritis.

Yang Dongmei D Ruan Ye Y Zheng Shengpeng S Xu Weilong W Hao Jian J

BMC medical genomics 20251022 1

BACKGROUND: The purpose of this study was to explore the role of immune modulation and iron metabolism disorder in the pathogenesis of osteoarthritis. METHODS: We performed a systematic analysis of datasets and immune infiltration of osteoarthritis and healthy cartilage tissues, to obtain differences in genes expression and immune cell infiltration related to iron metabolism between two samples. The iron metabolism-related genes with prognostic value was screened by Lasso and Cox regression, and ...[more]

PMID: 41126243

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