DNA methylation: a potential mediator between air pollution exposures and asthma control.

ABSTRACT:

Background

Exposure to air pollution is known to contribute to the development and exacerbation of asthma symptoms, impacting respiratory health through complex, not yet fully understood biological mechanisms. It is hypothesized that DNA methylation (DNAm) changes triggered by air pollutants may mediate these effects on asthma symptom control.

Objectives

We aimed to investigate the effects of air pollution on DNAm in peripheral blood and asthma control. We also explored whether DNAm could potentially mediate the relationship between air pollution exposure and asthma control.

Methods

This study included 651 participants with asthma exposed to ambient air pollutants, NO₂, PM_2.5, PM₁₀, O₃, elemental carbon (EC), and NOx. Self-r

SUBMITTER: Nguyen MN 

PROVIDER: S-EPMC12542048 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature