Nebulized dexmedetomidine for post-dural puncture headache after cesarean delivery: a systematic review and meta-analysis.

ABSTRACT:

Background

There are limited effective non-invasive treatment options for post-dural puncture headache (PDPH) following cesarean delivery. This meta-analysis aimed to investigate the efficacy and safety of nebulized dexmedetomidine in treating PDPH after cesarean delivery.

Methods

Electronic databases were systematically searched from the inception to March 2025. Primary outcomes included pain scores based on the numerical rating scale (NRS) and the visual analogue scale (VAS) at 6, 12, 24, 48, and 72 h after the intervention. Secondary outcomes included the need for epidural blood patch (EBP) and adverse events, such as bradycardia and dry mouth. The Cochrane Risk of Bias 2 (RoB 2) tool was employed to assess the quality of the included studies, and the certainty of evidenc

SUBMITTER: Yang Y 

PROVIDER: S-EPMC12542067 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature