Sarcopenic obesity exacerbates gastric cancer prognosis via increased intermuscular and visceral fat accumulation.

ABSTRACT:

Background

Ectopic fat distribution reflects patient's metabolic profile, shaping the tumor microenvironment, which may be a key prognostic indicator. Our study pursues to explore the independent and combined effects of muscle atrophy and abnormal fat distribution on survival in gastric cancer patients.

Method

This retrospective cohort study analyzed body composition in 283 gastric cancer patients from Center Hospital, Tianjin University (June 2016-May 2025) using pretreatment CT at L₃, assessing muscle mass, intermuscular, and visceral fat. Ectopic fat phenotypes included visceral obesity (increased visceral  adipose tissue, VAT) and myosteatosis (reduced skeletal muscle density, SMD). Associations between body composition parameters/phenotypes and progression-fr

SUBMITTER: Li CW 

PROVIDER: S-EPMC12542074 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature