SRAGE inhibits myocardial ischemia/reperfusion injuries via regulating Treg cells.

ABSTRACT:

Background

Regulatory T cells (Tregs) have been documented to accumulate in damaged myocardial tissue, where they play a pivotal role in attenuating excessive inflammatory responses during myocardial ischemia/reperfusion (I/R) injury. Concurrently, soluble receptor for advanced glycation end-products (sRAGE) has been demonstrated to alleviate myocardial I/R injury by suppressing inflammation, suggesting a potential involvement of Tregs in the inhibitory effects of sRAGE on myocardial I/R injury.

Methods

I/R surgery or glucose deprivation/reoxygenation was employed to explore myocardial injury and the related mechanisms by using cardiomyocyte-specific sRAGE knock-in mice or cultured cardiomyocytes. Potential molecular mechanisms were analyzed via western blotting, immunohisto

SUBMITTER: Liu J 

PROVIDER: S-EPMC12542090 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature