Inflammation of central nervous system fiber tracts is active in patients over six months post-intracerebral hemorrhage.

ABSTRACT: The occurrence and extent of central nervous system (CNS) fiber tract inflammation in chronic-phase intracerebral hemorrhage (ICH) patients are not well understood due to the heterogeneity of Wallerian degeneration (WD). This study aims to investigate the presence of CNS fiber tract inflammation in chronic-phase ICH patients and to characterize any inflammatory cells in the fiber tract. An in vivo translocator protein (TSPO)-PET study was undertaken in 22 ICH patients over 6 months after stroke who were admitted to the First Affiliated Hospital of Fujian Medical University or Tianjin Medical University General Hospital from April 2017 to June 2020. Twenty-three healthy controls or participants with various CNS diseases were included. Cerebral peduncle (CP) TSPO uptake was calculated as the

SUBMITTER: Gao Z 

PROVIDER: S-EPMC12542097 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature