Diagnostic importance of Treponema pallidum Tp0971 in the serological assessment of treatment efficacy for syphilis.

ABSTRACT: Over the last twenty years, there has been a global resurgence of infections caused by Treponema pallidum subsp. pallidum (T. pallidum), the bacterium responsible for syphilis. Presently, the T. pallidum IgG chemiluminescence immunoassay (CLIA) and T. pallidum particle agglutination (TPPA) are commonly employed for the investigation of potential syphilis cases through treponemal serological testing. The nontreponemal rapid plasma reagin (RPR) flocculation test is used to assess disease activity and test for cure or reinfection. Despite numerous limitations, RPR remains the best available serological standard for assessing the treatment effectiveness of patients at present. However, this method does not fully meet the requirements for treatment efficacy evaluation in syphilis patients becau

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12542151 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature