DNA methylation profiles and cancer in children conceived after assisted reproductive technology.

ABSTRACT:

Background

Epidemiological studies have shown a small but significantly increased risk of leukemia in children conceived by in vitro fertilization. Atypical DNA methylation patterns observed in pediatric cancers are suspected to occur in utero, and it is known that periconceptional conditions linked to assisted reproductive technologies (ART) are responsible for DNA methylation modifications.

Results

Using databases and systematic literature screens, we derived a list of cancer/leukemia genes (n = 1246 and n = 532 genes, respectively, corresponding to 1466 individual genes) and of differentially methylated genes (DMG) in leukemia (n = 2642) and pre-leukemia (n = 381). These lists were cross-referenced with DMG (n = 93) curated from 18 ART Epigenome-Wide Association Studies (

SUBMITTER: Ducreux B 

PROVIDER: S-EPMC12542189 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature