Triglyceride-glucose (TyG) index combined with C-reactive protein outperforms the TyG index alone in predicting stroke in arthritis patients: a nationwide prospective cohort study.

ABSTRACT:

Background

Arthritis patients exhibit a higher stroke risk, but effective predictive biomarkers are scarce. This research sought to examine and compare the associations between the triglyceride-glucose (TyG) index, its integration with C-reactive protein (CRP) (TyG-CRP), and stroke risk in these patients.

Methods

This research examined data from 3,419 arthritis patients participating in the China Health and Retirement Longitudinal Study (CHARLS), focusing on the occurrence of new stroke events as the main outcome. Examination of the association between the TyG index, TyG-CRP and stroke risk relied on Kaplan-Meier, Cox regression, and restricted cubic splines (RCS) analyses.

Results

During the 9-year follow-up period, 339 arthritis patients (9.9%) had their initial str

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC12542220 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature