Cardiometabolic multimorbidity, social activity, and joint trajectories of physical disability, depressive symptom, and cognitive function in mid-to-late life: a multicohort study.

ABSTRACT:

Background

There is limited evidence on the long-term associations between cardiometabolic multimorbidity (CMM) and multiple domains of functioning, and the potential role of social activity in these associations. We aimed to examine the associations between CMM and joint trajectories of physical disability, depressive symptom, and cognitive function, and whether social activity modifies these trajectories.

Methods

This multicohort study used pooled data of four prospective cohorts of adults from China, the UK, the USA, and Europe. Participants with complete information on cardiometabolic diseases (CMDs, including heart diseases, stroke, and diabetes) and social activity at baseline were included. Physical disability, depressive symptom, and cognitive function were measured

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12542226 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature