CT-derived proximal tibial bone density imbalance is associated with knee osteoarthritis.

ABSTRACT:

Background

Compartmental imbalance in proximal tibial bone density may contribute to the structural progression of knee osteoarthritis (OA), yet remains underexplored using quantitative imaging. This study investigated the association between compartmental proximal tibial bone density, measured using CT-derived Hounsfield units (HU), and knee OA.

Methods

This retrospective cross-sectional study analyzed 753 knees from patients who underwent lower-extremity CT, knee radiography, and orthoradiogram between 1995 and 2024 at a single tertiary center. The knees were categorized as OA (N = 238) or non-OA (N = 515) based on expert image review. The HU values were measured in three compartments: the medial plateau, lateral plateau, and central metaphysis. The absolute and relative H

SUBMITTER: Kang H 

PROVIDER: S-EPMC12542229 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature