Regulation of macrophages in the dorsal root ganglion through TGF-β1 inhibits painful traumatic neuroma.

ABSTRACT:

Background

The mechanisms underlying neuropathic pain in traumatic neuromas following peripheral nerve injury have become a major research focus in the field of pain medicine. Transforming growth factor-β1 (TGF-β1), an anti-inflammatory cytokine, is significantly elevated in the dorsal root ganglion (DRG) after peripheral nerve injury. This study investigates the role and mechanisms of TGF-β1 in traumatic neuroma formation and neuropathic pain.

Methods

In vivo, neuropathic pain-related behaviors, neuroma formation, activation of nerve fibers in the dorsal root ganglion (DRG), and macrophage polarization were evaluated in rats subjected to sciatic nerve transection (SNT) to examine whether TGF-β1 plays a role in preventing traumatic neuroma. In vitro, RAW 264.7 cells were sti

SUBMITTER: Xia C 

PROVIDER: S-EPMC12542251 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature