Design and Synthesis of Hybrid Compounds for Potential Treatment of Bacterial Co-Infections: In Vitro Antibacterial and In Silico Studies.

ABSTRACT: Background: The need for innovative therapeutic strategies to enhance patient outcomes has increased due to the rise in bacterial co-infections associated with COVID-19. Methods: In this study, ten hybrid compounds were synthesized by combining two known pharmaceutical scaffolds to enhance antibacterial activity and overcome resistance mechanisms. The synthesized compounds were evaluated for their antibacterial activity against five Gram-negative and seven Gram-positive bacterial strains. In silico pharmacokinetic and drug-likeness properties of selected active compounds (12-16, 19, 21, and 23) were predicted using the SwissADME web tool. Results: Compounds 12-16, 19, 21, and 23 demonstrated significant ant

SUBMITTER: Khwaza V 

PROVIDER: S-EPMC12542292 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature