Comprehensive genomic landscape of metastatic hormone-sensitive prostate cancer in the Chinese population.

ABSTRACT:

Background

Prostate cancer is the most common cancer in urology. While the genomic profiles and prognostic biomarkers of metastatic castration-resistant prostate cancer (mCRPC) have been well studied, the genomic characteristics of Chinese metastatic hormone-sensitive prostate cancer (mHSPC) and their association with clinical features remain incompletely characterized. This study aimed to characterize the genomic landscape of mHSPC in a Chinese cohort and explore correlations with clinical characteristics, with comparisons to data from the Stand Up to Cancer-Prostate Cancer Foundation (SU2C-PCF) cohort.

Methods

In this retrospective study, 52 patients diagnosed with mHSPC were enrolled, and tumor samples were subjected to targeted sequencing. Clinical, demographic, and path

SUBMITTER: Yang B 

PROVIDER: S-EPMC12542295 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature