Deep Brain Stimulation for VPS16-Related Dystonia: A Multicenter Study.

ABSTRACT:

Objective

The objective was to evaluate the effects of deep brain stimulation (DBS) in an international cohort of patients with VPS16-related dystonia.

Methods

This observational study collected preoperative and postoperative demographic, clinical, stimulation, genetic, neuroimaging, and neurophysiological data of medically refractory DYT-VPS16 patients with implanted DBS in 10 international centers. Motor symptoms and disability outcomes were assessed using the Burke-Fahn-Marsden Dystonia Rating Scale Motor (BFMDRS-M) and Disability (BFMDRS-D) scales. A cut-off threshold for considering response to DBS was set at 25% of BFMDRS-M improvement at the last follow-up (FU) compared to baseline.

Results

The cohort consisted of 26 participants (17 men, 65.4%). Age at dystoni

SUBMITTER: Svorenova T 

PROVIDER: S-EPMC12542321 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature