μ-Opioid Receptor Dynamics in the Parameningeal Tissue During Migraine Attacks.

ABSTRACT:

Objective

The possible impact of meningeal μ-opioid receptor (μOR) binding in migraine remains unknown. This study investigated μOR availability in the cranial parameninges involved in migraine initiation via nociceptor activation.

Methods

We used positron emission tomography with [¹¹C] carfentanil, and measured μOR availability in meninges and adjacent skull bone (parameningeal tissue [PMT]) under resting and sustained thermal pain threshold stress challenge conditions. μOR availability was compared between individuals with migraine in interictal and ictal phases and healthy controls. Furthermore, we examined the relationship between μOR availability and headache intensity, as well as the potential influence of sex on this measure.

Results

A total of 36 pa

SUBMITTER: Kim DJ 

PROVIDER: S-EPMC12542323 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature