The Scale of Neurodegeneration in Moderate-to-Severe Traumatic Brain Injury: A Systematic Review of Longitudinal Studies.

ABSTRACT:

Objective

Although moderate-to-severe traumatic brain injury (msTBI) was once considered a static neural event following resolution of acute injuries, numerous studies now demonstrate progressive losses to volume and white matter integrity in the months and years postinjury, leading to a paradigm shift in our understanding. These findings have yet to be synthesized. Therefore, our objective was to assimilate longitudinal studies of chronic msTBI to better elucidate the scale and timelines of neurodegeneration, regions of vulnerability, and ongoing gaps in the literature.

Methods

As per our published systematic review protocol (see PROSPERO CRD42019117548), 6 electronic databases were searched from inception to June 2024. Included studies examined adults (> 17) with msTBI, we

SUBMITTER: Sharma B 

PROVIDER: S-EPMC12542324 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature