Socioeconomic value of treatments for chronic idiopathic constipation in Japan.

ABSTRACT:

Background

Chronic idiopathic constipation (CIC) is a common disorder associated with socioeconomic burden. The aim of this study was to quantify the socioeconomic burden of CIC, including non-traditional value elements, and to compare the cost-effectiveness of 3 treatments for CIC with unique mechanisms of action: elobixibat 10 mg, linaclotide 0.5 mg, and lubiprostone 48 μg.

Methods

We compared medical costs and CIC-specific quality of life (QoL) among patients treated with elobixibat 10 mg, linaclotide 0.5 mg, and lubiprostone 48 μg using a Markov cohort simulation model of 4 mutually exclusive health states (CIC, unimproved, improved, and death) with 4-week cycles and a 2-year time horizon. In addition to costs and QoL scores, which were discounted at 2.0% per year, we co

SUBMITTER: Nakajima A 

PROVIDER: S-EPMC12542378 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature